A decade following the authorization of the Patient-Centered Outcomes Research Institute (PCORI), the significance and potential impact of comparative effectiveness research (CER) remains at the forefront of the health policy conversation. CER has offered an approach to evaluate the outcomes of different health care methods and identify which treatments matter most to patients. Comparative effectiveness research also has the potential to inform broader health care policy conversations on value, costs, and delivery system reform. This webinar outlined the various PCORI reauthorization bills and amendments that have been discussed by House and Senate committees to date. Our panel of experts explored some of the critical questions facing congressional staff and discuss potential next steps in the legislative process.